These proteins are catalytic chemicals called enzymes that target a virus’s genetic code and carve out tiny snippets of its RNA or DNA. “The gene-editing tool that Doudna and others developed in 2012,” Isaacson notes, “is based on a virus-fighting trick used by bacteria, which have been battling viruses for more than a billion years.”īacteria produce proteins to combat attackers. The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson (2021) 552 pages ★★★★★ Much more than a biography, this is the story of CRISPR and its potential to upend the way medicine is practiced in the 21st century. And they share the spotlight with dozens of other scientists as well as a handful of iconic figures in the biomedical establishment, including Francis Collins (National Institutes of Health), David Baltimore (California Institute of Technology), and James Watson (co-discoverer of DNA’s double helix). But there are four main characters: Jennifer Doudna, Emmanuelle Charpentier, George Church and Feng Zhang. The publisher markets the book as a biography and Doudna is the central subject. Four main characters Read Berkeleyside’s story on Walter Isaacson and the writing of the book.ĭoudna’s work, and that of her students, post-docs, and colleagues, as well as collaborators and rivals from other labs, are the subject of Walter Isaacson’s gripping account in The Code Breaker. And it won the Nobel Prize for Chemistry eight years later for a remarkable woman at the University of California, Berkeley, named Jennifer Doudna. The historic breakthrough that led to the now widespread use of CRISPR in biomedical labs around the world came only in 2012. CRISPR technology enabled scientists to create both vaccines in record time, bypassing the clumsy and time-consuming methods employed in vaccine development in the past. If you have received either the Moderna or the Pfizer/BioNTech vaccine against COVID-19, you are benefiting from a biomedical tool called CRISPR. Walter Isaacson at UC Berkeley while researching his book, ‘The Code Breakers.”

The code breaker walter isaacson